Acetophenazine ( Tindal )

Cymbalta / Yentreve ( duloxetine hydrochloride )

Cymbalta / Yentreve has been approved by the FDA for use in the treatment of major depression. Patients on antidepressants and their families or caregivers should watch for worsening depression symptoms, unusual changes in behavior, and thoughts of suicide, as well as for anxiety, agitation, panic attacks, difficulty sleeping, irritability, hostility, aggressiveness, impulsivity, restlessness, or extreme hyperactivity. Call the doctor if you have thoughts of suicide or if any of these symptoms are severe or occur suddenly. Be especially observant at the beginning of antidepressant treatment or whenever there is a change in dose.

Cymbalta / Yentreve addresses both the emotional and physical symptoms of depression. In clinical studies, many people began to show improvement in emotional and physical symptoms as early as one to four weeks. However, results vary from person to person. Give Cymbalta / Yentreve time to work. And don't stop taking it without talking to your doctor.

CLASS: Selective serotonin and norepinephrine reuptake inhibitor ( SSNRI ).
Generic name: Duloxetine hydrochloride.
Type: Antidepressant.

Cymbalta / Yentreve is not recommended for those under 18.


20 mg, 30 mg, and 60 mg.

Dosages: Actual dosage must be determined by a physician.

Start: 20mg daily.
Increases: 20mg as needed.
Maintenance: As low as possible in 24 hours.

Normal dosage: 60mg daily.

Problems with:
Liver Function: Inform your Doctor.
Kidney Function: Inform your Doctor.

Before taking: N/A
While taking: Your doctor may periodically check your blood pressure while you are taking Cymbalta.

Take With: with or without food.

Full Benefits In: One to four weeks.

Missed Dose(s): If within one hour take, if over an hour skip and then continue on your normal schedule. Never Take a Double Dose

If Stop Taking: Do not stop without consulting your physician and never abruptly.

Overdose: There is no specific antidote to Cymbalta / Yentreve. In case of acute overdose, treatment should consist of those general measures employed in the management of overdose with any drug.


You should NOT take Cymbalta / Yentreve ( duloxetine HCL ) if:

  • You are allergic to duloxetine hydrochloride or other ingredients in Cymbalta / Yentreve.
  • You currently or have recently taken monoamine oxidase inhibitor ( MAOI ).
  • You have uncontrolled narrow-angle glaucoma.
  • You are taking Mellaril® ( thioridazine ).

Do not take this drug if you are pregnant. ( Only take if the mother's or baby's life is endangered )

Do not take this drug if planning to become pregnant. Do not take if you are breast-feeding.

Talk with your doctor before taking Cymbalta / Yentreve if you have liver or kidney problems or glaucoma. Tell your doctor if you are pregnant or nursing or consume large quantities of alcohol. Be sure to let your healthcare professional know about all other prescription and nonprescription medicines you are taking.

Do not use if: You had negative reactions to this drug in the past. Cymbalta / Yentreve is not recommended for those under 18.

Cymbalta / Yentreve ( Symptoms or Effects )

In clinical studies for Cymbalta / Yentreve used for depression, the most common side effect was nausea. For most people, the nausea was mild to moderate, and usually subsided within one to two weeks.

Other most common side effects included ( listed in order of frequency ):

  • Dry mouth
  • Constipation
  • Decreased appetite
  • Fatigue
  • Sleepiness
  • Increased sweating

Most people were not bothered enough by nausea or these side effects to stop taking Cymbalta / Yentreve.



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