SAMe is used to treat depression, depression associated with Parkinson's disease, and epilepsy. SAMe is being used in the treatment of Alzheimer's, dementia, Fibromyalgia, and schizophrenia. SAMe is a nutrient which is naturally formed in the body. It appears to raise levels of certain neurotransmitters, which may be effective in not only treating depression but also working as a powerful antioxidant. SAMe may be used to treat Fibromyalgia and osteoarthritis. SAMe is involved in over 40 chemical reactions in the body. The beneficial effects of SAMe supplementation are extensive because this nutrient is involved in so many metabolic processes, including its role in serving to detoxify cell membranes and synthesize neurotransmitters. From acting as an antioxidant to raising serotonin levels in the brain, SAMe is one of the most important compounds to come to the market. Studies on the use of SAMe in maintaining normal joint function are also promising. Dietary Supplement - s-adenosyl-L-methionine. Supports Joint Comfort, Function and Mobility. 30 Enteric Coated Tablets - 400 mg each. SAMe is a stable, bio available form of S-adenosyl-L-methionine. These tablets are enteric-coated and blister-packed to prevent breakdown and inactivation of the ingredients. Dozens of clinical studies have demonstrated that SAMe supports joint comfort, function and mobility in the spine, hips and knees. It is important to the joints because of its critical role in cartilage formation. SAMe helps to form proteoglycans, which are used to renew the matrix of cartilage. The studies also show that SAMe helps support a positive outlook. It is able to cross the blood-brain barrier, where it affects the synthesis and activation of various proteins, such as neurotransmitters. SAMe also plays a role in trasmethylation. Transmethylation reactions affect the synthesis, activation, and metabolism of various bilogical molecules. Some compounds that SAMe methylates are phospholipids. This is a fundamental step in the mediation of cell to cell communication. SAMe is present in every living cell in the body and plays an important part in many critical cellular functions. However, levels of SAMe tend to decline with age.

Other name: S-Adenosyl-Mehtionine (SAM-e), ( S-Adenosyl-Methionine Disulfate Ditosylate), AdoMet.
Type: Antidepressant.

Strengths: 100 mg, 200 mg.

Dosages: Actual dosage must be determined by a physician.

Start: 400 mg.
Increases:  Determined by a physician and as needed.
Maximum: 1600 mg.

Normal dosage: 400 mg to 1600 mg daily.

Problems with:
Liver Function: N/A
Kidney Function: N/A

Before taking: Homocysteine levels.
While taking:  N/A

Take With: 1 hour before Meals or 2 hours after meals.

Full Benefits In: In 1 to 2 weeks.

Missed Dose(s): If within one hour take, if over an hour skip and then continue on your normal schedule.
Never Take a Double Dose.

If Stop Taking: Consulting your physician.

Overdose symptoms include: 
Overdose if Untreated:


Avoid alcohol while taking this drug.

Do not take this drug if you have high homocysteine levels.

Do not take this drug if you have cancer.

Do not take this drug if you are or have taken an MAO inhibitor in the last 2 weeks.

Do not take this drug if you are pregnant.

Do not take this drug if planning to become pregnant. Do not take if you are breast-feeding.

Do not give this drug to anyone under six months old. Only use drug in small doses at first if over sixty and with close monitoring.

Do not use if: You have bipolar disorder.

Inform your Doctor if:

  • you had negative reactions to this drug in the past.
  • if you are taking any other prescription or nonprescription drug;
  • if you plan to be under anesthesia or having any surgery in the next few months, also if you will be undergoing any medical tests. 
  • if you are on a special diet ( low-salt / low-sugar or any other ).

SAMe ( Symptoms or Effects )

Common: Anxiety, hyperactive, insomnia, mania, and mild digestive upset.


See physician if severe: 

See physician NOW:

Stop taking and see physician NOW:

SAMe ( Drug Interactions )

  • L-dopa



Top link
Contact us

Music Logo

Facebook Facebook
Twiitter Twitter
ipsyforum ipsyBlog Mental