iPsychology

Effexor (Venlafaxine Hydrochloride)

This medication is used in the treatment of depression. The extended release form of this medication is also used to treat anxiety.
Take this medication by mouth exactly as prescribed. During the first few days your doctor may gradually increase your dose to allow your body to adjust to the medication. Take this medication with food. Do not take this more often or increase your dose without consulting your doctor. Your condition will not improve any faster but the risk of serious side effects will be increased. Do not stop taking this drug suddenly without your doctor's approval. Your dose may need to be gradually reduced to prevent adverse effects.
This medication may initially cause dizziness and nausea as your body adjusts to the medication. Other side effects reported include sweating, loss of appetite, dizziness, dry mouth, anxiety, tremor, blurred vision, constipation, sleepiness, change in sexual ability. If any of these effects continue or become bothersome, inform your doctor. Notify your doctor if you develop any of these serious effects: rapid or irregular heartbeat, chest pain, severe headache, trouble breathing, painful or difficult urination, skin rash. This medication may cause drowsiness, dizziness, or clouded thinking. Use caution operating machinery or engaging in activities requiring alertness. If you notice other effects not listed above, contact your doctor or pharmacist.
Tell your doctor your medical history, especially of: kidney disease, liver disease, heart disease, high blood pressure, glaucoma, any allergies. Elderly persons may be more sensitive to the effects of this medication. Use with caution. This medication should be used only if clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known if this medication appears in breast milk. Consult your doctor before breast-feeding.
Tell your doctor of any over-the-counter or prescription medication you may take especially: MAO inhibitors (e.g., tranylcypromine, phenelzine, isocarboxazid, selegiline, furazolidone), other antidepressants, cimetidine, lithium, sedatives, narcotic pain relievers (e.g., codeine, morphine), seizure medication, certain migraine medicine (e.g., sumatriptan), medicine for weight control. It is recommended to avoid alcohol while using this medication. Do not start or stop any medicine without doctor or pharmacist approval.
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include sleepiness, irregular heartbeat, and seizures.
Laboratory tests may be done periodically while taking this medication to monitor the effects. See your doctor regularly.
Try to take each dose at the scheduled time. If you miss a dose, take it as soon as remembered; do not take it if it is near the time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.
Store this medication at room temperature between 59 and 86 degrees F (between 15 and 30 degrees C) away from heat and light. Do not store in the bathroom. Keep this and all medications out of the reach of children.


Effexor (venlafaxine hydrochloride) is a structurally novel antidepressant for oral administration.
It is chemically unrelated to tricyclic, tetracyclic, or other available antidepressant agents. It is
designated (R/S)-1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl] cyclohexanol hydrochloride
or (¡¾)-1-[¥á-[(dimethyl-amino)methyl]-p-methoxybenzyl] cyclohexanol hydrochloride and has
the empirical formula of C17H27NO2 HCl. Its molecular weight is 313.87.

Venlafaxine hydrochloride is a white to off-white crystalline solid with a solubility of
572 mg/mL in water (adjusted to ionic strength of 0.2 M with sodium chloride). Its octanol:
water (0.2 M sodium chloride) partition coefficient is 0.43.
Compressed tablets contain venlafaxine hydrochloride equivalent to 25 mg, 37.5 mg, 50 mg,
75 mg, or 100 mg venlafaxine. Inactive ingredients consist of cellulose, iron oxides, lactose,
magnesium stearate, and sodium starch glycolate.

WARNINGS
Potential for Interaction with Monoamine Oxidase Inhibitors
Adverse reactions, some of which were serious, have been reported in patients who have
recently been discontinued from a monoamine oxidase inhibitor (MAOI) and started on
Effexor, or who have recently had Effexor therapy discontinued prior to initiation of an
MAOI. These reactions have included tremor, myoclonus, diaphoresis, nausea, vomiting,
flushing, dizziness, hyperthermia with features resembling neuroleptic malignant
syndrome, seizures, and death. In patients receiving antidepressants with pharmacological
properties similar to venlafaxine in combination with a monoamine oxidase inhibitor, there
have also been reports of serious, sometimes fatal, reactions. For a selective serotonin
reuptake inhibitor, these reactions have included hyperthermia, rigidity, myoclonus,
autonomic instability with possible rapid fluctuations of vital signs, and mental status
changes that include extreme agitation progressing to delirium and coma. Some cases
presented with features resembling neuroleptic malignant syndrome. Severe hyperthermia
and seizures, sometimes fatal, have been reported in association with the combined use of
tricyclic antidepressants and MAOIs. These reactions have also been reported in patients
who have recently discontinued these drugs and have been started on an MAOI. Therefore,
it is recommended that Effexor not be used in combination with an MAOI, or within at
least 14 days of discontinuing treatment with an MAOI. Based on the half-life of Effexor, at
least 7 days should be allowed after stopping Effexor before starting an MAOI.
Sustained Hypertension , Venlafaxine treatment is associated with sustained increases in blood pressure in some patients.

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